The antimicrobial efficacy of Amferia’s technology platform and its safety in lab and animal studies have been verified in numerous pre-clinical studies published in peer-reviewed scientific journals.
The studies describe evidence of Amferia’s technology through fluorescence microscopy against multiple strains of bacteria, including resistant bacteria. An animal infection study demonstrates the real-time effectiveness of Amferia hydrogel in eradicating bacteria from a wound.
In 2022, Amferia’s technology platform was verified in a new form for potential spray-based applications. The base technology was reformulated as small particles that can be sprayed for applications in deep wounds. The results demonstrated excellent reduction of the broad bacterial bio burden including resistant bacteria up to 4 log reduction (or 99.99%) bacterial colonies. This study and others are now published in peer-reviewed scientific journals as listed below.
Pre-clinical studies in peer-reviewed scientific journals
- — Anti-biofilm coatings to medical implants, Atefyekta et. al. published in Acta Biomaterialia — 2019
- — Nanostructured elastomeric materials for biomaterial applications, Rajasekharan et. al. published in ACS Nano — 2020
- — Antimicrobial Peptide-Functionalized Mesoporous Hydrogels, Atefyekta, Blomstrand et. al. published in ACS Biomaterials Science and Engineering — 2021
- — Cross-Linked Lyotropic Liquid Crystal Particles Functionalized with Antimicrobial Peptides, Blomstrand et. al. published in International Journal of Pharmaceutics — 2022
- — Multifunctional Surface Modification of PDMS for Antibacterial Contact Killing and Drug-Delivery of Polar, Nonpolar and Amphiphilic Drugs, Stepulane et. al. published in ACS Applied Biomaterials — 2022
- — Lyotropic liquid crystal elastomers for drug delivery, Stepulane et. al. published in Colloids and Surfaces B: Biointerfaces—2023
- — Antibacterial and Hemolytic Activity of Antimicrobial Hydrogels Utilizing Immobilized Antimicrobial Peptides, Blomstrand et. al. published in International Journal of Molecular Sciences—2024
- — Antibacterial efficacy of antimicrobial peptide-functionalized hydrogel particles combined with vancomycin and oxacillin antibiotics, Stepulane et. al. published in
International Journal of Pharmaceutics — 2024
- Upcoming papers, under peer-review or preparation
- — In vivo biostability and endotoxin binding properties of a hydrogel functionalized with antimicrobial peptides, Blomstrand et. al.
