How antimicrobial hydrogel can revolutionize clinical treatments
Amferia’s innovative, flexible hydrogel can be adapted to many medical applications. One of the first products we’re developing for our antimicrobial platform is a wound care dressing.
The soft, flexible Amferia antimicrobial hydrogel can be integrated with wound dressings of various shapes and sizes. The product we’re developing will be shelf-stable for up to eighteen months—and, when applied to wounds, will bind and kill bacteria for up to five days before dressings need to be changed.
As antibiotics continue to be less effective against certain resistant bacterial strains, the potential market for this technology is enormous.
The potential market for this technology is enormous
Amferia’s hydrogel is a flexible solution that can be potentially adapted to multiple applications where killing bacteria is critical—with the added advantage that it kills even resistant bacteria. A few examples of potential applications are listed below. Some we are already developing. Others, we’re actively seeking partners to develop with us.
Amferia’s first product for human care is our antimicrobial hydrogel wound dressing. Amferia is developing several dressing formats that feature our patented hydrogel, starting with a non-adhesive hydrogel dressing for acute wounds, while pipeline products cater to the numerous needs within wound care while keeping the antimicrobial property intact.
When applied as a solid wound dressing pad, Amferia’s antimicrobial hydrogel can bind and kill 99.9% of bacteria, providing an effective, clean environment for wound recovery.
The global advanced wound care market is estimated to be 7 billion USD today and growing at a rate of 5% annually.
Amferia’s proprietary hydrogel acts as the contact layer to the wound, binding and killing bacteria while providing a moist environment conducive for wound healing.
Today, Amferia has ongoing clinical investigations in Europe and we are seeking CE marking and FDA clearance on this product.
The global advanced wound care market is estimated to be 7 billion USD today and growing at a rate of 5% annually.
Another potential application for Amferia hydrogel comes in the form of a patch that can clear the skin of bacteria before a surgical procedure. A recent study we conducted on human skin demonstrated that Amferia hydrogel kills up to 99.99% bacteria on skin surface within the first three hours of application.
Adhering a protective hydrogel patch to the incision site prior to surgery eradicates skin flora, providing a bacteria free site of surgery. In emergency wards, where patients may be waiting in a non-sterile environment prior to surgery, a bacteria-killing patch can reduce complications and potentially save lives.
The flexible nature of our hydrogel platform allows us to apply the patented bacteria-killing hydrogel in many forms—including an aerosol spray. Small particles of the antimicrobial hydrogel can be dispersed through an aerosol to cover broader areas of the skin and wounds. A pipeline product being developed at Amferia is a spray that can be applied directly to wounds or skin, especially deep wounds with high bacterial presence.
The spray system enables the same antimicrobial mode of action as the wound dressing while ensuring high surface area, which will enable eradication of bacteria from deep and uneven wounds.
This scientific basis for this product has been evaluated scientifically and published in a peer-reviewed journal.
Short-term implantable medical devices such as urinary catheters are widely used in hospitals and nursing homes to relieve urinary retention and incontinence.
In these types of medical devices, the most common and life-threatening complication is catheter associated urinary tract infections (CAUTI), which affect over 10 million patients every year with high economic cost and patient suffering. Antimicrobial resistance has made it difficult to treat CAUTI via conventional antibiotics.
With an increasingly ageing population and rising costs to treat CAUTIs, a strong need exists for innovative anti-bacterial catheters that prevent bacterial colonisation on the catheter walls.
In collaboration with Chalmers University of Technology, Amferia has begun ongoing research into enabling our technology as a whole catheter or as coatings to existing catheters. The base technology, amphiphilic antimicrobial hydrogel may be developed into tough silicone-like materials or can be tailored as coatings to silicone surfaces. Both these prospects are being tested today as proof-of-concepts and published in scientific articles.
Get in touch for partnership, licensing and distribution
Amferia is interested to engage in discussions with companies who have business interest in utilising our innovation in possible product combinations through partnership structures. Within wound care, Amferia has the possibility to offer finished or semi-finished products for commercial or distribution partnerships.
Amferia is working in partnership with a manufacturer to produce a high volume of Amferia wound care dressings. Amferia currently operates a clinical production site in Mölndal, Sweden, for testing and evaluating these products. Informed by those results, we are building capacity for a high volume production of wound dressings with an established partner.
Addressing antibiotic resistance the sustainable way
Over time, harmful bacteria continue to evolve. In what is rapidly becoming a health care crisis, many bacteria have already developed antibiotic resistance (ABR). Simple infections such as skin wound infections can become lethal. Today, across the world, many types of bacteria have evolved to an extent where none of our antibiotics are effective against them.
For example, Methicillin Resistant Staph. Aureus (MRSA) evolved from an ordinary bacteria. It has become what’s known as a “superbug,” resistant to many common antibiotics. A skin infection involving MRSA can develop life-threatening complications. MRSA is only one of many superbug strains. At current rates of microbial evolution, WHO warns, drug-resistant infection may kill more people than cancer by 2050.
Innovations such as Amferia’s focus on addressing antibiotic resistance through relying less on antibiotics and more on the roles of good hygiene, education on antibiotic use and smarter antimicrobial technologies that do not increase the risk of new resistance.
Using bio-inspired materials derived from our immune system to kill bacteria comes with numerous advantages. These materials can target bacteria without harming our own cells. They offer potent local action at the site of an infection, with no leaching into the body or environment.
In this context, Amferia’s innovation and wound care dressing is more than a plaster, but rather a new platform that aids and supports the mitigation of antibiotic resistance.
Amferia AB signs major contract with Orkla Wound Care
December 4, 2023
Amferia has recently signed an exclusive Animal Health Private Label License and Purchase Agreement with Orkla Wound Care covering the Nordic region, Germany, Spain and Portugal for a period of 3 years with a possibility for extension.
Anand Rajasekharan, CEO of Amferia — “Orkla Wound Care’s market leadership in wound care will spearhead Amferia’s vision of addressing antibiotic resistant wound infections in animal health. We are inspired by this partnership, which will bring our innovation together with a leading brand to a market where there is considerable need for new solutions. Amferia’s innovation has already received strong interest and positive feedback from veterinarians from across Europe, who immediately notice the potential of our new antimicrobial material within wound and infection management.”
The joint partnership with Orkla Wound Care will enable Amferia’s technology, through Orkla leading brand Snögg Animal Care, to reach the wider European veterinary market where wound care and infection prevention is of prime importance. This has been intensified with the growing threat of antibiotic resistant infections. Amferia and Orkla Wound Care’s partnership will build on extensive data and feedback from Amferia’s clinical testing across Europe. The joint efforts will aim to market the products under the brand Snögg Animal Care from 2024.
Maria Lundman Hedberg, CEO of Orkla Wound Care— “We are excited about our collaboration with Amferia and bringing their innovative products to market under the brand Snögg Animal Care. Amferia's pioneering antimicrobial wound dressing aligns seamlessly with our dedication to providing cutting-edge solutions to veterinarians through our Snögg Animal Care range. This collaboration strengthens our position as a leader in wound care, both for humans and animals.
Amferia's antimicrobial amphiphilic hydrogel kills bacteria, even resistant bacteria without harming the body. The material was developed through several years of research in collaboration with Chalmers University of Technology and the first product from this technology platform is a wound-care dressing for dry-to-low exuding wounds. Amferia's innovative, anti-microbial solution can be used on wide-ranging wounds from simple skin injuries, post-operative wounds to chronic wounds and trauma / burn wounds. The WHO predicts that antibiotic-resistant infections, including those from wounds could become one of the leading causes of both illness and death over the next ten years. The material is being investigated for continuous development in several other areas, including sprays for deep wounds, and coatings for implants and a variety of catheters. Read more about the products, team, technology and publications at www.amferia.com
About Orkla Wound Care
Orkla Wound Care has a long tradition of developing, manufacturing and distributing market leading products within wound care and first aid. Orkla Wound Care is a part of the Orkla group, a public listed company on the Norwegian Stock Exchange, known for its active portfolio management targeting fast-growing consumer segments and markets.
Amferia AB is happy to announce the appointment of Ingvar Karlsson as the Chief Financial Officer. Ingvar has extensive background in financial management within a broad area including the life-science industry.
Ingvar has a solid background as the CFO from both public and private companies covering Life science and Medtech, Automotive and premium consumer goods spanning over 40 years. Today, he works both on the Board of cutting-edge life-science SME’s as well as provide service as CFO for their successful growth. Ingvar’s extensive knowledge in financial management, supply chain processes and capital planning of life science companies, will be important for Amferia’s scale-up journey in both human and animal wound care.
Anand Kumar Rajasekharan, CEO of Amferia − “It is an honour to work with Ingvar, whose impressive knowledge of the field and guidance greatly strengthens Amferia’s position as a competent and cutting-edge SME with precision in its numbers. We look forward to jointly grow the company, as we set our sights on global growth of Amferia both in human and animal wound care.
Ingvar Karlsson, CFO of Amferia − “I look forward working with the team at Amferia. The company has a very interesting journey ahead. Amferia is en route towards internationalization and distribution of its products through partnerships in multiple countries. I am glad to work with companies like Amferia improving healthcare for both humans and animals. ”
Amferia selected as one of Sweden’s best, young deep technology companies by Ny Teknik’s prestigious 33-listan
November 20, 2023
The significance of the list is that Amferia, as one among the 33 young Swedish companies is deemed to have high potential to become future growth companies. The companies selected to be on the list after rigorous evaluation by the jury, are judged to be innovative, have scalable business models and have the potential to grow quickly on the Swedish and global market.
Infections are a difficult healthcare problem, exacerbated by antibiotic resistance. Amferia’s innovative antimicrobial material is an effective, safe and sustainable way to address life threatening bacterial infections, especially within the filed of medical devices. This is equally important in both human and animal health, and we are bringing products built on our technology rapidly to the market.
The recognition by Nyteknik is an important achievement for Amferia attesting to our measured yet rapid progress of a deep technology breakthrough innovation to the clinic. And most importantly, our deepest gratitude to our collaborators in the clinics who clearly saw the need and importance of our technology in addressing an acute global healthcare threat.
Our colleague Edvin Blomstrand now holds a PhD in Materials Science from Chalmers
September 26, 2023
Amferia is thrilled to announce that our exceptional Research Engineer, Edvin Blomstrand, has successfully defended his doctoral thesis titled "Amphiphilic Hydrogels Functionalized with Antimicrobial Peptides for Wound Care" at Chalmers tekniska högskola. He now proudly holds the esteemed title of Doctor of Philosophy in Materials Science. During his PhD journey, Edvin's contributions have played a pivotal role in shaping our product development at Amferia. We couldn't be more excited to have him continue this remarkable journey with us. With him on board, we are prepared more than ever to pursue our goals, push the boundaries of innovation, and make a meaningful impact in our field.
Join us in congratulating Dr. Blomstrand on this brilliant achievement, and we look forward to the amazing things to accomplish together in the future!
A warm welcome to Amferia’s new Board Members
September 4, 2023
We are proud to introduce the addition of three remarkable individuals to our Board of Directors. Each new member brings a wealth of diverse experience and knowledge to our team which will further strengthen Amferia’s position in addressing antibiotic resistance and infection management.
Alexandra De Wever Treschow has over 15 years of leadership experience within life science management and consulting including 4 years as CEO of diagnostics company Aprovix. Prior to that, Alexandra was managing partner of Stockholm-based inRikta Analys. She is co-founder and currently serves as CEO of NORDx Pharma. She holds a PhD in Gene Therapy from Karolinska Institutet and an MBA from Quantic School of business and Technology, USA.
Ulrika Ågren is presently an Investment Manager at Almi Invest focusing on medtech, healthtech and greentech. Ulrika has over 20 years of experience in the med-tech industry with specialisations in intellectual property, innovation portfolio management, project management and business development. She is a certified board member and previously worked for global medtech companies such as Mölnlycke Health Care where she was Global IP Director and the biotech company Cellartis (now Takara Bio). Before joining Almi Invest Ulrika coached HealthTech startups at Sahlgrenska Science Park.
Jonas Bergman serves as an Investment Director at Chalmers Ventures. He brings with him great insight into the operations of med-tech companiesand how they can create long-term value. Jonas has a Master ofScience in Engineering fromChalmers University of Technology and has been CEO of both listed and unlisted life-sciencecompanies for many years. He has also worked as a management consultant forover 7 years with a particular focus in Biotech.
Amferia’s first human clinical study published
June 26, 2023
We are thrilled to share that our dedicated team at Amferia in collaboration with Chalmers tekniska högskola has published a randomised controlled study in the Journal of Wound Care that demonstrates the outstanding antibacterial performance of our hydrogel wound dressing. We studied our wound dressing on intact human skin as a model to evaluate the speed and efficacy of the dressing to kill bacteria — and the results were truly remarkable!
By utilizing the Amferia Antimicrobial Hydrogel technology, we eradicated bacteria when placed in contact with skin within a short period of three hours.
By utilizing the Amferia Antimicrobial Hydrogel, bacteria was eradicated within three hours.
These findings demonstrate the potential of our antibacterial wound dressing to significantly reduce the risk of infection in wounds, offering new possibilities for improved patient outcomes. This study lays the foundation for our future clinical studies in human wounds.
Amferia raises SEK 15.4 million to launch innovative antimicrobial wound care dressing
January 27, 2023
The financing was raised from Almi Invest, Chalmers Ventures, and with several angel investors to support launch of Amferia’s first product, a wound care dressing with a patented hydrogel that actively combats infections and kills antibiotic-resistant bacteria.
Amferia's innovative, anti-microbial solution can be used on wide-ranging wounds from simple skin injuries, post-operative wounds to chronic wounds and trauma / burn wounds. The WHO predicts that antibiotic-resistant infections, including those from wounds could become one of the leading causes of both illness and death over the next ten years.
“I am grateful to all our committed investors: Every year, nearly 1 million people die globally because of infections caused by antibiotic-resistant bacteria and at least a quarter of those infections begin with a simple wound on the skin. Amferia's wound care solution is a game-changer and will save lives. The resistance problem is even more challenging within the animal health sector.”, says Agneta Edberg, Chairperson of Amferia.
Amferia's wound care solution is a game-changer and will save lives.
Amferia's patented material, an antimicrobial amphiphilic hydrogel, has been developed through several years of research in collaboration with Chalmers University of Technology and contains molecules inspired by body’s own immune system. The material instantly kills all bacteria (even antibiotic resistant) by binding to and disrupting their cell membranes, all without damaging the body’s own cells or entering the bloodstream. The first product from this technology is a hydrogel wound-care dressing for dry-to-low exuding wounds, while the material is also being investigated for development in several other areas, including sprays for deep wounds, and coatings for implants and a variety of catheters. In September of 2022, Amferia launched its first wound dressings for animal health in Sweden and plan on expanding across Europe during 2023. In parallel, the company is preparing to file for regulatory clearance in the US for human health.
The wound care market currently generates sales for over US $ 2 billion globally with a projected CAGR of 5 %. However, existing alternatives on the market often contain antibiotics that carry the risk of causing resistance or antiseptics that may harm body cells and negative environmental impact.
We already have our first product on the market for animal wound care in Sweden
“The investment enables us to perform three key tasks: scale up and launch our products for animal health in Europe, file for FDA clearance of the application for human health and thirdly initiate more clinical studies in both market segments. This ambition is supported by the fact that we already have our first product on the market for animal wound care in Sweden”, says Anand Kumar Rajasekharan, CEO of Amferia.
Pre-clinical research on new antimicrobial spray and coating technology published
January 26, 2023
Amferia announced today that it has, in collaboration with Chalmers University of Technology, published two important scientific articles in peer-reviewed journals that describe the pre-clinical studies of its platform technology, Amphiphilic Antimicrobial Hydrogel as sprays and coatings for various medical device applications.
Amferia’s platform technology is an amphiphilic antimicrobial hydrogel material that can rapidly bind and kill all types of bacteria, even resistant bacteria, without harming the body. In an effort to enable further applications of this material, Amferia collaborated with Chalmers University of Technology to test and develop the patented technology as sprayable formulation and as coatings fight off bacterial infections in medical devices.
Today, the extensive pre-clinical data from this research has been published in two scientific articles in peer-reviewed journals*. The research was built on the formulation of the Amphiphlic Antimicrobial Hydrogel as small discrete particles, which were then further developed as sprayable form for wound care and as a coating on existing materials like silicone catheters. The results from these studies show powerful antimicrobial effect, safety to human cells while being stable in biological environments such as serum.
The material has been shown to be effective against many different types of bacteria, including those that are resistant to antibiotics
Martin Andersson, Professor at Chalmers University and Co-founder of Amferia − “Our innovation can have a dual impact in the fight against antibiotic resistance. The material has been shown to be effective against many different types of bacteria, including those that are resistant to antibiotics, such as Methicillin-resistant Staphylococcus aureus (MRSA), while also having the potential to prevent infections and thus reduce the need for antibiotics,.”
The research was undertaken based on the strong potential of Amferia’s technology, but also based on a clear need from the human and animal health care system on fighting infections in the context of deep infected wounds as well as for various medical devices such as urinary catheters. Amferia and Chalmers will continue to collaborate on this research and are planning to further study the use of the new formulations in clinical settings, both for human and animal care.
We are seeing the great potential of our technology going beyond wound care into the realm of broader medical devices
Anand Rajasekharan,CEO of Amferia − “This is an important achievement for Amferia as we are seeing the great potential of our technology going beyond wound care into the realm of broader medical devices such as coatings and sprayable systems. Our current product is a wound dressing and we look forward to follow-up the same with these pipeline products that will have a stronger impact for addressing antibiotic resistance.”
Agneta has a solid background from the global Life science and Medtech field spanning over 30 years in leading roles such as; Sales &Marketing Director of Pharmacia (Pfizer), Senior VP and CEO of Mylan NordicPharmaceuticals, CEO of NM Pharma and more recently as the COO of Bactigaurd that manufactures a variety of antimicrobial device. Today, she works on theBoard of cutting-edge life-science SME’s guiding the companies for future success. Agneta’s extensive knowledge in the life science industry will be important for Amferia’s scale-up journey in both human and animal wound care.
Anand Kumar Rajasekharan, CEO of Amferia − “It is an honour to work with Agenta, whose impressive knowledge of the field and guidance greatly strengthens Amferia’s position as a competent and cutting-edge SME. We look forward to jointly achieve the upcoming key milestones such as the first product launch for animal health, FDA and CE regulatory processes for human health and establishing a successful sales and marketing foundation for Amferia.”
Agneta Edberg − “Amferia is a company every board person wishes to work for. The technology offers a paradigm shift in wound care with nontoxic properties still killing bacteria, even the resistant ones. In a world where antimicrobial resistance is an increasing challenge to humanity, I am grateful to be a part of reducing that threat”
Amferia at the European Wound Management Association (EWMA) congress 2022 in Paris
May 17, 2022
EWMA is an important congress that brings together clinicians and healthcare industry for important discussions within wound care for humans and animals. Amferia is eager to present our science, antimicrobial technology and introduce our first wound dressings for animal and human wound care. We welcome all attendees to our stand located in
room 252A at the congress venue, Palais des Congrès de Paris, to know more about Amferia and clinical evidence for human and animal wound care as well as for an introduction to our soon-to-be launched wound dressings for animal wound care. We also invite all attendees to our scientific talk at the symposium for Veterinary Wound Healing Association (VWHA) on 24th May at 08:45 hrs room 252A.