Amferia announced findings that antibiotic-resistant bacteria can regain its sensitivity to antibiotics when combined with the company’s peptide-hydrogel. Results of a collaboration between Chalmers University of Technology and Amferia show that antibiotics can have a 64 times higher bactericidal effect when used together with Amferia’s proprietary material, whose antibacterial properties are also greatly enhanced by this combination.
Peptides have long been known to possess potent antimicrobial properties, destroying bacteria by disrupting the integrity of cell membranes rather than by chemical processes. Until recently, the problem with applying peptides to medical needs like wound care has been their fragility. Peptides are easily destroyed by naturally occurring enzymes and salts in the body. Amferia’s innovation is a hydrogel material that protects the peptides without compromising their bacteria-destroying structures.
In order for this material to be used clinically--in combination with standard treatments like antibiotics, for example—researchers had to ensure that the hydrogel does not negatively affect the antibiotic's effectiveness when used simultaneously.
The new findings demonstrate the peptide-hydrogel’s substantial potential for applications in various medical devices and infection treatments.
The study produced surprisingly positive results: when applied in concert with Amferia hydrogel, the effectiveness of antibiotics tested was elevated significantly. Drug synergism is defined as the combined effect of different drugs, where the resulting effect is greater than the sum of their individual effects. Chalmers researchers discovered exactly that synergism when using the peptide material and antibiotics together against certain antibiotic-resistant bacteria. This had not been shown before.
The peptide material was evaluated in combination with two different antibiotics, oxacillin and vancomycin. The bacteria involved in the trials were two types of staphylococci (S. aureus), one of which is resistant to multiple antibiotics.
The most powerful effect in the study was measured against the multi-resistant S. aureus. When the Amferia hydrogel was combined with oxacillin, an antibiotic to which S. aureus had developed a resistance, the combination of hydrogel and oxacillin lowered the effective concentration of oxacillin 64-fold compared to when the antibiotic was used alone. At concentrations below the level where bacteria are classified as resistant, oxacillin regained its effectiveness against the bacteria.
